منابع مشابه
Management of intracerebral hemorrhage–use of statins
Intracerebral hemorrhage (ICH) is a neurologic injury resulting in significant morbidity and mortality. Statins play a significant role in primary and secondary prevention of cardiovascular and cerebrovascular ischemic events. Despite clear benefits of statins in ischemic stroke, post hoc analyses of some studies suggest there may be a link between statin therapy and development of ICH. Direct ...
متن کاملStatins and intracerebral hemorrhage: collaborative systematic review and meta-analysis.
BACKGROUND A recent large, randomized trial suggested that statins may increase the risk of intracerebral hemorrhage. Accordingly, we systematically reviewed the association of statins with intracerebral hemorrhage in randomized and observational data. METHODS AND RESULTS We screened 17 electronic bibliographic databases to identify eligible studies and consulted with experts in the field. We...
متن کاملApolipoprotein E, statins, and risk of intracerebral hemorrhage.
BACKGROUND AND PURPOSE Apolipoprotein E (ApoE) genotypes have been associated with lobar intracerebral hemorrhage (ICH). Although statins have been associated with an increased risk of ICH, meta-analyses have not consistently shown a statin-induced risk of ICH. Here, we test whether hypercholesterolemia (HC) and ApoE polymorphisms affect the risk of ICH by statin use. METHODS The Genetic and ...
متن کاملEffect of statins on intracerebral hemorrhage outcome and recurrence.
BACKGROUND AND PURPOSE 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, have been associated with improved outcome after ischemic stroke and subarachnoid hemorrhage but an increased risk of incident intracerebral hemorrhage (ICH). We investigated (1) whether statin use before ICH was associated with functional independence at 90 days, and (2) whether survivors e...
متن کاملStatins and intracerebral hemorrhage: a retrospective cohort study.
BACKGROUND A recent post hoc analysis of a large randomized trial in patients with cerebrovascular disease suggested that statins may increase the risk of intracerebral hemorrhage (ICH). OBJECTIVE To examine the association between statins and ICH in patients with recent ischemic stroke in a population-based setting. DESIGN Retrospective propensity-matched cohort study with accrual from Jul...
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ژورنال
عنوان ژورنال: Circulation
سال: 2011
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.111.055269